There is absolutely no question that the game that will produce Fantasy Football Week 3’s most productive game is the matchup between the Detroit Lions and San Francisco 49ers. So load up on players from those teams this week, because it is going to be a hell of a ride.

That game between the Lions and 49ers will have everything you want in a football game. They’ll have prolific receivers, dynamic running backs, accurate QBs, and even an off-field element of former coaching mates in Rod Marinelli and Mike Martz squaring off. This game has everything but defense, which is why this matchup of lowly teams could be the most productive game in terms of fantasy points.

Aspect #1: No Defense – Both of these teams are horrible on the defensive end. Last week the 49ers gave up 30 points to a Seattle team without its 4 best wide receivers. And in the same week, the Detroit Lions gave up 48 points to the Green Bay Packers. So, as I alluded to before, no defense means plenty of offense. That means players that great players that have been on the fringe of playing well, such as RB Frank Gore and WR Roy Williams, will have plenty of opportunity to shine and take advantage of a lackluster defense. So if you can swing a trade for them and “buy low,” then you may have a chance at getting one of those two players on the upswing.

Aspect #2: Coach Hate – Mike Martz, the offensive coordinator for the 49ers, was the offensive coordinator for the Lions just last year. But the head coach of the Detroit Lions, Rod Marinelli, let Martz go because he didn’t like Martz’s style and wanted a more efficient offense. Well, clearly, when you fire someone because they don’t do things your way, there is usually no love lost between you and the fire-ee. So you can expect that Mike Martz, a point-scoring addict, will be inclined to put as many points on the board as possible. He’ll do everything in his power to show Marinelli up, even if that means running up the score. You can rest assure that Martz has spent some extra time in the film room looking at all of the weaknesses in the Lions defense, and he will be fully prepared to take advantage of them come Sunday.

Aspect #3: Accurate QBs – If you didn’t my memo before the season started, this boy J.T. O’Sullivan can sling the ball in Martz’s offense, and he proved that last week against the Seattle Seahawks. Can he deliver an encore? Of course he can. And he will. He is a very accurate thrower who is not afraid to take chances, and he seems to take well to coaching, and Martz has certainly done a great job of coaching him up. As for the Lions quarterback, Jon Kitna, obviously he is a very accurate passer as well. He throws interceptions a little too frequently, but against this 49ers defense, there aren’t any cornerbacks that are going to be real close to Roy Williams or Calvin Johnson when Kitna puts the ball in the air, so interceptions should be at a premium on his end. That said, you can’t go wrong with either quarterback in this game, so starting one of them, almost over anybody else you have would be the wise decision. I just scooped J.T. O’Sullivan off waivers in my fantasy football league, so there’s a good chance he may be available in your league as well.